| Title | Sociotropy and Autonomy Relationship to Antidepressant Drug Treatment Response and Endogenous-Nonendogenous Dichotomy |
| Publication Type | Journal Article |
| Year of Publication | 1992 |
| Authors | Peselow ED, Robins CJ, Sanfilipo MP, Block P, Fieve RR |
| Journal | Journal of Abnormal Psychology |
| Volume | 101 |
| Pagination | 479-486 |
| Keywords | Behavioral biology - Human behavior 12512, Hominidae [86215] Anthropology Human Medicine, Medical Sciences Behavior Human Ecology Neurology Pharmacology Psychiatry Primates Mammalia Vertebrata Chordata Animalia 05500, Medical Sciences Human Medicine, Nervous system - Pathology 21002, Pathology - Therapy 20506, Pharmacology - Neuropharmacology 22026, Psychiatry - Psychopathology, psychodynamics and therapy 22024, Social biology and human ecology 07004 |
| Abstract | This study evaluated the relationship of sociotropic and autonomous personality traits with response to pharmacotherapy for 217 depressed outpatients using the Sociotropy-Autonomy Scale. Sociotropy was related to nonendogenous depression, whereas autonomy was related to endogenous depression. Subjects who has high autonomous-low sociotropic traits showed greater response to antidepressants (and greater drug-placebo differences) than those who had high sociotropic-low autonomous traits (who showed no drug-placebo differences). Hierarchical multiple regression analysis showed that the sociotropy - autonomy, but not the endogenous-nonendogenous, distinction was a predictor of drug treatment response. The combination of endogeneity and autonomy predicted response to placebo. If replicated, these findings may enable better matching of patient traits to various treatment modalities for depression.
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